ISALTIS

Our Applications

General Metabolism

Minerals for the human metabolism

ISALTIS is developing and manufacturing minerals for proper functioning of the general metabolism. They are organic minerals : it means that the mineral part is vectorised by an organic moety of vegetal origin, in order to enhance its solubility and bioavailability.

  • Magnesium to treat fatigue, stress, migraines…
  • Calcium for stronger teeth and bones
  • Iron for hemoglobin and myoglobulin, as well as a cofcator of many enzymes
  • Manganese for osteoporosis, as an antioxidant and anti-aging. It also participates in the action of many enzymes and in particular the synthesis of insulin (and therefore the control of blood sugar)
  • Zinc for immunity, skin and hair health, vision, fertility, etc.
  • Copper: Powerful antioxidant, copper helps fight oxidative stress and cell aging, it also boosts the immune system, and participates in the action of many enzymes such as melanin or glucose oxidation
Learn more »
Pharmaceutique

ISALTIS is developping and manufacturing high purity mineral salts, GMP certified, used as pharmaceutical active ingredients to treat mineral deficiencies such as calcium, magnesium or iron deficiency. We also produce antiseptic ingredients such as zinc undecylenate, and dermatological ingredients such as lithium gluconate.

Our APIs are produced at Giavudan-Lavirotte factory, which is GMP certified by the french ANSM, and FDA approved.

Our organic minerals have a high bioavailability, linked to their biomimetic nature. Our know-how consists in decorating the mineral with an organic vector of plant origin in order to increase its solubility and its bioavailability. These are “premium” or “third generation” mineral salts with high added value, both in their design and in their quality, and are adapted to the needs of our pharma customers.

 The efficiency of our APIs is proven by clinical studies.

Our key pharma ingredients are :

  • Calcium salts : calcium glucoheptonate and calcium glycerophosphate 
  • Magnesium: magnesium gluconate and magnesium glycerophosphate
  • Iron: ferrous gluconate (organic form highly tolerated by human metabolism, without side effects and tasting less pronounced than other forms)
  • Trace elements: Copper, zinc and manganese gluconates
  • Zinc undecylenate and undecylenic acid: anti-bacterial and anti-fungal agents
  • Lithium gluconate : topical active ingredient against atopic dermatitis
  • Potassium nitrate : for teeth hypersensitivity

QUALITY AND REGULATORY

Our APIs have necessary documentation for our customers to deposit market authorizations (MAA).

The list of available CEP can be checked on EDQM website :

https://extranet.edqm.eu/publications/recherches_CEP.shtml

Our updated GMP certificates are listed on the website of Eudra GMP :

http://eudragmdp.ema.europa.eu/inspections/gmpc/searchGMPCompliance.do

This documents as well as complete DMF/CTD dossiers can be obtained on demand, as well as the FDA related documents.

Our APIs are proposed under several pharmacopeias : PE, USP and BPC.

ISALTIS owns its own analytical laboratories for physico-chemical and microbiological analysis. They are able to perform our own heavy metals analysis.

Learn more »
Nutrition

Mineral salts are essential for human metabolism. They are less and less present in food because of industrial methods of food production, and the depletion of soils in minerals. Whether they are macrominerals like calcium or magnesium, present in significant quantities in the human body, or as trace elements (zinc, copper, manganese …) they each have a preponderant role in metabolism. Our organic mineral salts are used to treat deficiencies linked to our lifestyles. Our organic minerals have a high bioavailability, linked to their biomimetic nature. Our know-how consists in decorating the mineral with an organic vector of plant origin in order to increase its solubility and its bioavailability. These are “premium” or “third generation” mineral salts with high added value, both in their design and in their quality, and are adapted to the needs of our customers. Their efficiency is proven by clinical studies, and they are very well documented.

Here is a non-exhaustive list of food applications in which they are used :

FOOD SUPPLEMENTS

Magnesium to treat fatigue, stress, migraines…

Calcium for stronger teeth and bones

Manganese for osteoporosis, as an antioxidant and anti-aging. It also participates in the action of many enzymes and in particular the synthesis of insulin (and therefore the control of blood sugar)

Zinc for immunity, skin and hair health, vision, fertility, etc.

Copper: Powerful antioxidant, copper helps fight oxidative stress and cell aging, it also boosts the immune system, and participates in the action of many enzymes such as melanin or glucose oxidation

We offer for example by type of mineral:

  • Calcium: glucoheptonate and calcium glycerophosphate
  • Magnesium: gluconate and magnesium glycerophosphate
  • Iron: iron gluconate (organic form highly tolerated by human metabolism, without side effects and tasting less pronounced than other forms)
  • Trace elements: Copper, zinc and manganese gluconates

OUR FLAGSHIP ACTIVES

GIVOMAG (magnesium glycerophosphate) is a highly bioavailable magnesium chelate with no side effects on the metabolism, and is part of the 3rd generation mineral salts, called “premium”. Its effectiveness is proven by clinical studies, and a study carried out with LALLEMAND has proven its synergistic effect with probiotics, thanks to the presence of phosphorus in its composition. It does not contain additives and has a very low level of heavy metals. ISALTIS owns the GIVOMAG trademark and can authorize its use under license.

GIVOMAG has its own website: www.givomag.com for more information

GIVOCAL (calcium glycerophosphate) is a highly bioavailable calcium chelate with no side effects on the metabolism, and is part of the 3rd generation mineral salts, called “premium”. It is in particular the salt of choice for the most sensitive applications (example: milk for premature babies or babies suffering from serious diseases). The fact that it contains phosphorus and calcium in proportions similar to hydroxyapatite makes it the best choice of calcium salt for remineralizing bones and teeth. Its effectiveness is proven by clinical studies, and a study conducted with LALLEMAND has also proven its synergistic effect with probiotics. It does not contain additives and has a very low level of heavy metals. ISALTIS owns the GIVOCAL trademark and may authorize its use under license.

SPORTS NUTRITION

Our minerals are perfectly suited to sports nutrition, especially drinks thanks to their solubility. Traditionally, sodium and potassium are the most used but it should not be forgotten that calcium and magnesium participate in the good contraction of the muscles also. In this sense, we have developed HYDRA 4G, a mixture based on the 4 key minerals of sports practice, which contributes to hydration and the proper functioning of muscles during sports practice. Infant nutrition Our organic minerals are well tolerated by the body, do not cause side effects and have good organoleptic properties. They are therefore recommended for nutritious products intended for children. In particular, our calcium glycerophosphate is very suitable for baby milks to replace traditionally used inorganic salts (calcium carbonate for example), source of colic for young children.

INFANT NUTRITION

Our organic minerals are well tolerated by the body, do not cause side effects and have good organoleptic properties. They are therefore recommended for nutritious products intended for children. In particular, our calcium glycerophosphate is very suitable for baby milks to replace traditionally used inorganic salts (calcium carbonate for example), source of colic for young children.

Synergistic effect with probiotics

Several studies carried out in partnership with our parent company Lallemand, show a good synergy and compatibility between organic minerals and probiotic strains. These studies have given rise to several commercial developments of food supplements made up of probiotics and organic minerals.

Listening to our customers, at the heart of our priorities

Isaltis relies on quality and customer service to maintain the trust of its partners. The human size of our SME allows us to respond quickly and adapt to the demands of our customers, located around the world. We are focusing on innovation and intensifying our R&D activities at the two sites in order to expand our product ranges and offer our customers new and effective ingredients that meet their needs.

Quality and regulatory

We follow GMP and FSSC22000 principles to manufacture our nutrition actives. They are FDA approved too.

Learn more »
Sports

SPORTS NUTRITION

Eating well is important for all living things, and it is all the more crucial for athletes. It must not only be healthy, balanced and varied but also meet energy needs. Food supplements and sports drinks are developed to compensate for any deficiencies, and improve performances of athletes.

ISALTIS develops and manufactures a range of organic minerals capable of improving the sportsman’s contributions, increasing their performance and their hydration.

A dedicated active : HYDRA4G

ISALTIS has developed HYDRA4G, a synergistic mixture of 4 minerals specifically designed for optimal hydration of the athlete and proper functioning of the muscles, thanks to its intake of magnesium and calcium, in addition to the potassium and sodium traditionally present in sports drinks .

HYDRA4G is a powder and can be used for various finished forms: sachets, capsules, tablets, drinks, shots …

GIVOBIO LA range (lactates)

ISALTIS produces zinc lactate (Givobio La / Zn) and magnesium lactate (Givobio La / Mg), which are the most recommended forms in sports nutrition. Indeed, lactate increases the bioavailability of the mineral, but is also converted by metabolism in the form of energy for the muscles, the heart and the brain.

Other organic minerals

ISALTIS offers highly bioavailable organic forms of several other minerals: magensium, potassium and calcium but also zinc, copper, manganese (natural antioxidants) … for complete supplementation of athletes.

Learn more »
Immunity

MINERALS, KEY ACTORS OF IMMUNITY

ISALTIS is designing and developing organic mineral salts having high bioavailability. Some of them are particularly critical for the immune system, in particular zinc salts.

ZINC AND IMMUNITY

Zinc is THE mineral of immunity. Weak immune defenses are directly correlated to zinc deficiencies, which are more and more prevalent in our modern societies. Zinc is an essential cofactor of the enzymes involved in immune defense. ISALTIS offers different zinc salts with different solubility and zinc content:

  • zinc gluconate
  • zinc citrate
  • zinc lactate

MAGNESIUM, AN ANTI-FATIGUE ALLY

Beyond the pure immune function, it is important to guarantee the body a minimum of energy to fight against the surrounding infections. Magnesium deficiencies can cause fatigue and stress that decrease the body’s immune response capacity. ISALTIS designs and manufactures several magnesium salts:

  • magnesium glycerophosphate
  • magnesium lactate
  • magnesium glucoheptonate
  • magnesium gluconate
  • magnesium citrate

Our ferrous gluconate can also be an ally for the body.

All these active ingredients can be used in nutrition (food supplements, drinks, food fortification, etc.). Most of them are also GMP Pharma certified and have a complete pharmaceutical file for use in medicine.

Learn more »
Personal care

ISALTIS RANGE OF MINERALS FOR SKIN AND HAIR CARE

Minerals are crucial in oral administration for the proper functioning of the metabolism, but their topical application also has proven effects. In Skin & Hair Care, minerals are involved in:

  • hydration of the skin
  • trapping of free radicals
  • UV protection
  • Wound healing
  • Cellular respiration
  • Skin ageing
  • structure of collagen and elastin
  • restoration of the skin barrier
  • production of sebum…

The amount of each mineral present in the skin and hair decreases with age, and varies according to the diet of each. It is therefore important to have an external supply of minerals for the beauty of the skin and hair.

Our flagship actives are:

-Zinc Gluconate (Mineralis Gu / Zn) having antibacterial and pore-reducing efficacy proven by clinical studies. It is also useful as a mordant for hair dyes. Mineralis Gu / Zn is COSMOS certified

-Calcium glycerophosphate (Furdentyl) which restores the natural barrier of the skin and strengthens the hair

-Copper gluconate (Mineralis Gu/Cu) which protects the skin from the harmful effects of the sun and acts as an antioxidant

-Manganese gluconate (Mineralis Gu/Mn) which acts against aging of the skin

-Magnesium gluconate (Mineralis Gu/Mg) for sensitive skin

These active ingredients comply to European cosmetic standards, and are manufactured at our Lyon site according to GMP standards.

THE RANGE OF MICROBIOLOGICAL ATIVES

In partnership with Lallemand cosmetics division, the world specialist in yeasts and bacteria, Isaltis is offering the following range of microbiological active ingredients:

prebiotics: LallHair P&R, Lallbiome 300
probiotics (tyndallized): Lallbiome 201 and 202
postbiotics: Lallskin Zn and Lallskin Hydra

NUTRICOSMETICS

The Lallemand / Macco / Isaltis group know-how in nutrition has enabled us to develop an offer of finished nutricosmetic products, namely food supplements in various forms (capsules, capsules, tablets, ampoules, shots, etc.) intended for the beauty of skin and hair.

The documentation is available in the “Documents” tab on the home page of the site and our sales representatives are available for more information.

Learn more »
Oral Health
ISALTIS, A LEADING PRODUCER OF ORAL CARE ACTIVES
ISALTIS is producing a full range of actives for Oral Care applications (toothpastes, mouthwash, professionnal tretaments…) manufctaured in GMP conditions. They are used by the major Oral Care multinationals, and also smaller but innovative Oral Care companies.
We are particularly focusing on :
– Treating dentin hypersensitivity : with potassium nitrate (Furdentyl NiK), potassium oxalate (Furdentyl KOx), strontium acetate (Furdentyl AcSr), strontium chloride (Furdentyl CSr)
– Prevent dental cavities : with calcium glycerophosphate (Furdentyl), a natural alternative to fluorides
– prevent gum bleeding : with aliminium lactate (Furdentyl LaAl)
– provide an antibacterial and antiplaque effect : with zinc gluconate (Mineralis GuZn), Zinc lactate (Furdentyl LaZn), Zinc citrate (Furdentyl CiZn) and Zinc phosphate (Furdentyl ZnP)
Among the list, Mineralis GuZn and Furdentyl are COSMOS certified.
Learn more »
Chemical Specialties

Fine chemicals for industrial applications

ISALTIS group is developping and manufacturing fine chemicals based on minerals for industrial applications : barium, strontium, zinc salts…such as pyrotechnics, the automotive industry or catalysis via nuclear fuels, paint and glass.

These mineral salts of very high purity require strict control over particle sizes and impurities (especially heavy metals) in order to function properly in their final applications. For the same mineral salt, we offer several ranges of particle size distribution and impurity specifications, two important parameters which are analyzed on site in our laboratories.

They are REACH Registered.

Industrial applications brochure – 2019

Learn more »